The University of Texas at Dallas School of Behavioral and Brain Sciences

Karen M. Rodrigue

Associate Professor
Program Head, Psychology PhD

Research Interests

Understanding factors that contribute to individual differences in brain and cognitive aging over the lifespan, utilizing neuropsychology assessment, structural and functional MRI and PET imaging techniques

Curriculum Vitae


Email: [email protected]
Phone: 972-883-3738
Office: VP_820
Campus Mail Code: VP10
Website: Cognitive Neuroscience of Aging Lab


Dr. Karen Rodrigue is a leading researcher in the area of age-related changes in the brain in healthy aging and their impact on cognitive performance, as well as the study of the health modifiers of the neurocognitive aging process. Dr. Rodrigue recently examined the role of amyloid-beta deposition in non-pathological aging and investigated the effects of genetic risk and vascular risk factors on the accumulation of this Alzheimer’s disease biomarker. She is known for her cross-sectional and longitudinal studies of structural changes in the aging brain, the impact of hypertension on brain and cognitive health, and for studying the role of brain iron accumulation with aging. Dr. Rodrigue has been awarded a K99/R00 “Pathway to Independence” Award from the National Institute on Aging and, in 2007, her dissertation work on brain iron accumulation in aging was recognized with a Dissertation Research Award from the American Psychological Association. In 2013, Dr. Rodrigue was named a “Rising Star” by the American Psychological Society. She received her bachelor’s degree from Loyola University, her master’s degree from Emporia State University, and her PhD from Wayne State University in Detroit, Michigan.

Recent and Selected Representative Publications

Recent Articles in Peer-Refereed Journals

Pongpipat, E. E., Kennedy, K. M., Foster, C. M., Boylan, M. A., Rodrigue, K.M. (in press). Functional connectivity within and between fronto-parietal and default mode networks during n-back: An adult lifespan PPI investigation. Brain Connectivity.

Boylan, M. A., Pongpipat, E. E., Foster, C. M., Webb, C. E., Rodrigue, K. M., Kennedy, K. M. (2021). Greater BOLD variability across the adult lifespan relates to poorer cognitive outcomes. Cerebral Cortex, 31(1), 562-574.

Foster, C. M., Kennedy, K. M., Daugherty, A. M., Rodrigue, K. M. (2020). Influence of Iron and Beta-amyloid Deposition on Entorhinal Cortex and Hippocampal Subfield Volumes in the Aging Brain. Neurology, 95(18), e2586-e2594. *Article selected for Editorial Commentary.

Webb, C. E., Foster, C. M., Horn, M. M., Kennedy, K. M., Rodrigue, K. M. (2020). Beta-Amyloid Deposition is Predictive of Poorer Mnemonic Discrimination in Cognitively Normal Older Adults. NeuroImage, 221, 117199. Epub 2020 Jul 29. PMID: 32736001

Rodrigue, K. M., Daugherty, A. M., Foster, C.M., Kennedy, K. M. (2020). Striatal iron content is linked to reduced fronto-striatal brain function under working memory load. NeuroImage, 210, 116544.