The University of Texas at Dallas School of Behavioral and Brain Sciences

Greg Dussor

Associate Professor
Fellow, Eugene McDermott Professor

Research Interests

Pain, with an emphasis on chronic headache disorders such as migraine.

Curriculum Vitae

Contact

Email: [email protected]
Phone: 972-883-2385
Office: BSB_10.538
Campus Mail Code: BSB14
Website: Pain Neurobiology Research Group, Center for Advanced Pain Studies and Texas Pain Research Consortium

Biography

Dr. Greg Dussor’s research focus is on uncovering pathological mechanisms and therapeutic targets for migraine headache. Since the most likely mechanism contributing to migraine pain is activation of peripheral nociceptive signaling from the meninges, experiments in the Dussor laboratory have focused on identifying cellular mechanisms of dural afferent activation/sensitization as well as understanding plasticity at the central terminals of these neurons. The laboratory has identified targets within the meningeal nociceptive system including acid-sensing ion channels (ASICs), several TRP channels, and IL-6 signaling mechanisms. His team has also developed and optimized several preclinical behavioral models for studying migraine. More recently, they have begun to investigate mechanisms that may contribute to the higher prevalence of migraine in women. These studies include a focus on the hormone prolactin as well as mechanisms that may mediate differential signaling through neuropeptide systems such as calcitonin gene-related peptide (CGRP).

Dr. Dussor was a recipient of a Future Leaders in Pain Research award from the American Pain Society and is a 2020 Mayday Fellow. He serves on the editorial boards of Pain, Pain Reports, Molecular Pain, Headache, the Journal of Headache and Pain, the Journal of Neuroscience, and he is a member of the advisory boards of the Migraine Research Foundation and the Association of Migraine Disorder’s new Migraine Science Collaborative.

Recent and Selected Representative Publications

Recent Articles in Peer-Refereed Journals

Lackovic J, Price TJ, Dussor G. (2020) De novo protein synthesis is necessary for priming in preclinical models of migraine. Cephalalgia. 2020 Nov 17:333102420970514. doi: 10.1177/0333102420970514.

Avona A, Mason B, Lackovic J, Wajahat N, Motina M, Quigley L, Burgos-Vega C, Loomis C, Garcia-Martinez L, Akopian A, Price T, Dussor G. (2020). Repetitive stress in mice causes migraine-like behaviors and CGRP-dependent hyperalgesic priming to a migraine trigger. Pain. Jun 10. doi: 10.1097/j.pain.0000000000001953. PMID: 32541386.

Avona A, Burgos-Vega C, Burton MD, Akopian A, Price TJ, Dussor G. (2019) Dural calcitonin gene-related peptide produces female-specific responses in rodent migraine models. J Neurosci. May 29;39(22):4323-4331.

View more of Greg Dussor’s publications