The University of Texas at Dallas School of Behavioral and Brain Sciences

Colleen G. Le Prell

Area Head, Communication Sciences and Disorders, Program Head, Communication Sciences and Disorders PhD
Emilie and Phil Schepps Professorship in Hearing Science

Research Interests

Noise-induced hearing loss, hearing loss prevention, supra-threshold hearing disorders

Curriculum Vitae


Email: [email protected]
Phone: 972-883-3018
Office: CD_J216
Campus Mail Code: CD


Dr. Colleen Le Prell is one of the leading researchers in the area of hearing loss prevention. Her work has emphasized the identification of cell death pathways activated by noise, and assessment of therapeutic agents that prevent cell death and hearing loss. Dr. Le Prell has served as the president of the National Hearing Conservation Association and serves on task forces and working groups for multiple professional organizations. She served as the lead editor on two Springer Handbook of Auditory Research editions (2012: Noise-Induced Hearing Loss: Scientific Advances; 2016: Translational Research in Audiology, Neurotology, and the Hearing Sciences), and was co-editor on the 2015 Oxidative Stress in Applied Basic Research and Clinical Practice: Free Radicals in ENT Pathology. Dr. Le Prell received her bachelor’s degree from the University of Minnesota at Morris and her master’s and doctoral degrees from the University of Michigan.

Recent and Selected Representative Publications

Recent Articles in Peer-Reviewed Journals

Le Prell, C. G. Otoprotectants — from research to clinical application, Seminars in Hearing, manuscript accepted for publication.

Le Prell, C. G. Effects of noise exposure on auditory brainstem response and speech-in-noise tasks: A review of the literature, International Journal of Audiology, 2018 Dec 18:1-30. doi: 10.1080/14992027.2018.1534010. [Epub ahead of print]

Le Prell, C. G. Siburt, H., Lobarinas, E., Griffiths, S., and Spankovich, C. (2018) No reliable association between recreational noise exposure and threshold sensitivity, distortion product otoacoustic emission amplitude, or word-in-noise performance in a college-student population. Ear and Hearing, 39(6):1057-1074. doi: 10.1097/AUD.0000000000000575.

Campbell, K.C.M. and Le Prell, C.G. (2018). Drug-induced ototoxicity: Diagnosis and monitoring. Drug Safety, 41(5):451-464. doi: 10.1007/s40264-017-0629-8.

Grinn, S.K.*, Wiseman, K.B.*, Baker, J.A*, and Le Prell, C. G. (2017). Hidden hearing loss? No effect of common recreational noise exposure on cochlear nerve response amplitude in humans. Frontiers in Neuroscience, 11:465. doi: 10.3389/fnins.2017.00465.

Kil, J., Lobarinas, E., Spankovich, C., Griffiths, S., Antonelli, P.J., Lynch, E.D., Le Prell, C. G. (2017). Safety and efficacy of Ebselen for the prevention of noise-induced hearing loss: A randomized double blind placebo-controlled phase 2 clinical trial, The Lancet, 390(10098):969-979. doi: 10.1016/S0140-6736(17)31791-9.

View more of Colleen Le Prell’s publications