The University of Texas at Dallas School of Behavioral and Brain Sciences

Francesca M. Filbey

Professor
Bert Moore Chair in BrainHealth

Research Interests

Neurobiological mechanisms underlying reward-motivation

Curriculum Vitae

Contact

Email: [email protected]
Phone: 972-883-3311
Office: CBH_2.720
Campus Mail Code: CBH 10
Website: Filbey Lab

Biography

My primary research focus is in determining the mechanisms that drive reward-seeking and motivated behavior. Using addiction as a model, I utilize inter-disciplinary approaches to address questions related to the neural development and adaptations that occur in the mesocorticolimbic dopaminergic-reward circuitry. The significance of this research is in advancing the understanding of reward mechanisms to facilitate prevention and intervention of self-regulatory dysfunction. The potential societal impacts of this research is high given that addictive disorders cause an extensive burden in terms of morbidity, mortality, and public health costs, yet treatment strategies are only modestly effective. I have led several successful, large research projects involving imaging, genetics, neuropsychological assessments, biochemical assays and clinical data in several substance abusing populations, with focus on cannabis use disorders. These studies culminate in over 800 well-characterized individuals across various populations and age groups.

Recent and Selected Representative Publications

Recent Articles in Peer-Refereed Journals

Filbey FM, Beaton D, Prashad S. (2021). The contributions of the endocannabinoid system and stress on the neural processing of reward stimuli. Prog Neuropsychopharmacol Biol Psychiatry. 2021;106:110183. Epub 2020/11/23. doi: 10.1016/j.pnpbp.2020.110183. PubMed PMID: 33221340.

Yoo, H. B., Moya, B. E., & Filbey, F. M. (2020). Dynamic functional connectivity between nucleus accumbens and the central executive network relates to chronic cannabis use. Hum Brain Mapp. doi:10.1002/hbm.25036

Prashad, S., Dedrick, E. S., and Filbey, F. M. (2018). Cannabis users exhibit increased cortical activation during resting state compared to non-users. Neuroimage, 179, 176-186. doi:10.1016/j.neuroimage.2018.06.031

Filbey, F.M., Joseph Dunlop, Jessica Baine, Tyler Rhinehardt, Ariel Ketcherside, Samuel DeWitt, (2016). fMRI study of neural sensitization to hedonic stimuli in long-term, daily cannabis users. Human Brain Mapping, 36 (10): 3431-3443.

Filbey, F.M., Aslan, S., Calhoun, V., Spence, J.S., Dasmaraju, E., Caprihan, A., and Segall, J. (2014). Long-term effects of marijuana use on the brain. Proceedings of the National Academy of Sciences, 111 (47): 16913-16918. doi: 10.1073/pnas.1415297111

View more of Francesca Filbey’s publications