Explore our sensory tissue high throughput assay analyses

Human and mouse DRG transcriptome profiles contrasted with other tissues

How similar are human and mouse DRG transcriptome profiles ? Which DRG-specific genes are expressed in neuronal subpopulations, and which are expressed in glial subpopulations ? What are the underlying transcription factor based regulatory program that drive these changes ? Are there axonally transported mRNAs in the DRG sensory neurons ?

  • Ray, Pradipta; Torck, Andrew; Quigley, Lilyana; et al; Comparative transcriptome profiling of the human and mouse dorsal root ganglia: an RNA-seq-based resource for pain and sensory neuroscience research. PAIN, 159(7):1325 - 1345, Wolters Kluwer, July 2018. Journal DOI link.

  • Translational profiling of rodent nociceptors under a Chemotherapy Induced Peripheral Neuropathy model

    What are the transcriptional and translational changes that are undergone in mouse DRG in response to Paclitaxel treatment ? What are the functional consequences of translational changes ? What are putative regulatory programs driving such change ?

  • Megat, Salim; Ray, Pradipta; Moy, Jamie; et al; Nociceptor translational profiling reveals the Ragulator-Rag GTPase complex as a critical generator of neuropathic pain. Journal of Neuroscience, 2019, 39 (3) 393-411. Journal DOI link.

  • Transcriptome profiling of human DRG samples with and without associated pain

    What are the transcriptomic correlates of neuropathic pain ? How do transcriptional changes affect individual patients ? What pathways are turned on / off ? Are there sex specific differences ?

  • North, Robert; Li, Yan; Ray, Pradipta; et al; Electrophysiological and transcriptomic correlates of neuropathic pain in human primary sensory neurons, Brain, 2019, Brain 142 (5), 1215-1226. Journal DOI link
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    Sex differences in the human tibial nerve transcriptome

    How similar are human male and female mRNA profiles in the tibial nerve ? Are the sex-differentially expressed genes involved in nociception, pain, inflammation, immune function or a combinaton of these ? Does the sex dimorphic abundance of transcripts have its basis in glial cells, immune cells, peri- and epi-neurial cells, or neuronal axonally transported transcripts ?

  • Ray,P. et al (2018). Sex-differential gene expression in the human tibial nerve involves key genes implicated in pain, inflammation, and neuro-immunity, Frontiers in Neuroscience, 2019, Journal DOI link.

  • Transcriptome differences between cultured DRGs in human and mouse

    How similar are human DRG tissue cultures compared to the in vivo tissue in terms of its RNA profile ? Are there sex differences in the DRG cultures ? Are there species differences in the DRG cultures ? Can we identify genes primarily expressed in post-mitotic cells (and cells dependent on post-mitotic cells for survival) in the mammalian DRG based on the cultured DRG profiles ?

  • Transcriptomic analysis of native versus cultured human and mouse dorsal root ganglia focused on pharmacological targets, Andi Wangzhou, Lisa A McIlvried, Candler Paige, Paulino Barragan-Iglesias, Carolyn A Guzman, Gregory Dussor, Pradipta R Ray, Robert W Gereau, Theodore J Price, 2019, bioRxiv, 766865, biorXiv link